Public Dissemination Event

El Puerto de Santa María, 3rd October 2019

Pseudo-albinism in sole (Solea senegalensis): the role of the transcriptome and microbiome



Patricia I.S. Pinto1; Cláudia Guerreiro1; Rita Costa1; Juan F. Martinez-Blanch2; Carlos Carballo3,4; Francisco Codoñer2; Manuel Manchado3,5; Deborah M Power1


1Centre of Marine Sciences (CCMAR), Universidade do Algarve, Campus de Gambelas, 8005-139 Faro, Portugal;

2LifeSequencing, Parc Cientific Universidad De Valencia, Edif. 2, C/ Catedrático Agustín Escardino Benlloch, 9, 46980 Paterna, Spain

3Instituto de Investigación y Formación Agraria y Pesquera (IFAPA) Centro El Toruño, Camino Tiro de Pichon s/n, Cadiz, Spain

4Universidad de Málaga, Departamento de Microbiologia, Campus de Teatinos, 29071, Málaga, Spain

5“Crecimiento Azul", Centro IFAPA El Toruño, Unidad Asociada al CSIC”



Senegalese sole is an economically important species with high potential for aquaculture. Its intensive cultivation has been however threatened by the development of infectious diseases or by the appearance of body shape or pigmentation abnormalities, mainly derived from imbalances at critical stages during metamorphosis. Pseudo-albinism is a pigmentation disorder, that affects Senegalese sole under intensive rearing conditions and can negatively affect its commercialization. Although some of the factors that cause pseudo-albinism have been identified, such as imbalanced diets at pre-metamorphosis, very little is known about the physiological characteristics of pseudo-albino fish besides the visible disruption of pigmentation at the level of the skin. In this work, we tested the hypothesis that pigmentation abnormalities are an overt signal of more generalised modifications in tissue structure and function, using as target tissues two important innate immune barriers, the skin and intestine, and their microbiomes. The results confirmed that sole pseudo-albinism is associated with generalised changes in the skin and gut structure and modifications in the gut microbiome. This study generated molecular resources for sole (transcriptomes and microbiomes) and “Omics” technologies for microbiome studies were developed and optimized. The resources and technologies have been used in other tasks of Algae4A&B to evaluate the benefits of using microalgae extracts and purified compounds as additives to improve Senegalese sole aquaculture.



This research has been funded by H2020 European Funds MSCA-RISE project 691102 (Algae4A&B) and the institutional project CCMAR/Multi/04326/2013 from the Portuguese Foundation for Science and Technology (FCT). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the abstract.